Computerized system and method for building a system of test components for a healthcare orderable procedure

ABSTRACT

A computerized system and method of building a system of test components for an orderable healthcare procedure is provided. An orderable healthcare procedure is received and associated with a discrete ontology concept. An ontology is traversed for the discrete ontology concept to identify test components related to the discrete ontology concept. The test components related to the discrete ontology concept are identified.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. Ser. No. 11/028,379, filed onJan. 3, 2005, the disclosure of which is hereby incorporated byreference. This application is related to commonly assigned U.S.application Ser. No. 11/028,262, filed Jan. 3, 2005, the disclosure ofwhich is hereby incorporated by reference in its entirety herein.

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

Not applicable.

TECHNICAL FIELD

The present invention relates generally to the field of computersoftware. More particularly, the invention relates to a system andmethod for building a system of test components for a healthcareorderable procedure.

BACKGROUND

An ontology is a semantically structured controlled vocabulary.Currently, ontologies of molecular biological interest are orientedtoward the research community. These ontologies focus primarily onfunctional attributes of molecular entities and do not meet therequirements for use in the clinical community, such as healthcareorganizations, hospitals, physician's offices and clinical healthcarelaboratories. The research ontologies do not represent the molecularentities targeted by the tests currently performed in clinicaldiagnostics in a standardized and machine readable format.

Furthermore, designing and implementing a computerized medical recordssystem is a lengthy and complex process that is currently performedmanually. Currently, a database administrator must manually determinethe proper individual molecular diagnostic tests to be associated withan orderable procedure. A system and method for automatically proposingmolecular diagnostic test components to be associated with an orderableprocedure would also be beneficial.

SUMMARY

In one embodiment of the present invention, a method of building asystem of test components for an orderable healthcare procedure isshown. An orderable healthcare procedure is received and associated witha discrete ontology concept. An ontology is traversed for the discreteontology concept to identify test components related to the discreteontology concept. The test components related to the discrete ontologyconcept are identified.

In another embodiment of the present invention, a computerized systemfor building a system of test components for a orderable healthcareprocedure is provided. The system comprises a receiving component forreceiving an orderable healthcare procedure and an associating componentfor associating the orderable healthcare procedure with a discreteontology concept. The system further comprises a traversing componenttraversing an ontology for the discrete ontology concept to identifytest components related to the discrete ontology concept and anidentifying component for identifying test components related to thediscrete ontology concept.

In yet another embodiment of the present invention, a computerizedsystem of building a system of test components for an orderableprocedure is provided. The system comprises means for receiving anorderable healthcare procedure and means for associating the orderablehealthcare procedure with a discrete ontology concept. The systemfurther comprises means for traversing the ontology for the discreteontology concept to identify test components related to the discreteontology concept and means for identifying test components related tothe discrete ontology concept.

BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS

The present invention is described in detail below with reference to theattached drawing figures, wherein:

FIG. 1 is a block diagram of a computing system environment suitable foruse in implementing the present invention;

FIG. 2 is a flow diagram of a method for traversing defined relationshippaths in an ontology and building a system for an orderable procedure ofresults or test components in accordance with an embodiment of thepresent invention;

FIG. 3 is a screen displaying a departmental order catalog and selectionof an orderable in accordance with an embodiment of the presentinvention;

FIG. 4 is a screen displaying details of an orderable in accordance withan embodiment of the present invention;

FIG. 5 is a screen displaying association of an orderable to anavigational ontology concept in accordance with an embodiment of thepresent invention;

FIG. 6 is a screen displaying the association of an orderable with anavigational ontology concept in accordance with an embodiment of thepresent invention;

FIG. 7 is a screen displaying possible molecular diagnostic tests forthe discrete concept for the orderable in accordance with an embodimentof the present invention.

FIG. 8 is a screen showing selection of molecular diagnostic testsassociated with the discrete concept associated with the orderable inaccordance with an embodiment of the present invention; and

FIG. 9 is a screen displaying an automatic build system for theorderable procedure comprising likely results or test components for theorderable in accordance with an embodiment of the present invention.

DETAILED DESCRIPTION OF THE INVENTION

With reference to FIG. 1, an exemplary medical information system forimplementing the invention includes a general purpose computing devicein the form of server 22. Components of server 22 may include, but arenot limited to, a processing unit, internal system memory, and asuitable system bus for coupling various system components, includingdatabase cluster 24 to the control server 22. The system bus may be anyof several types of bus structures, including a memory bus or memorycontroller, a peripheral bus, and a local bus using any of a variety ofbus architectures. By way of example, and not limitation, sucharchitectures include Industry Standard Architecture (ISA) bus, MicroChannel Architecture (MCA) bus, Enhanced ISA (EISA) bus, VideoElectronic Standards Association (VESA) local bus, and PeripheralComponent Interconnect (PCI) bus, also known as Mezzanine bus.

Server 22 typically includes or has access to a variety of computerreadable media, for instance, database cluster 24. Computer readablemedia can be any available media that can be accessed by server 22, andincludes both volatile and nonvolatile media, removable andnon-removable media. By way of example, and not limitation, computerreadable media may comprise computer storage media and communicationmedia. Computer storage media includes volatile and nonvolatile,removable and non-removable media implemented in any method ortechnology for storage of information, such as computer readableinstructions, data structures, program modules, or other data. Computerstorage media includes, but is not limited to, RAM, ROM, EEPROM, flashmemory or other memory technology, CD-ROM, digital versatile disks(DVD), or other optical disk storage, magnetic cassettes, magnetic tape,magnetic disk storage, or other magnetic storage devices, or any othermedium which can be used to store the desired information and which canbe accessed by server 22. Communication media typically embodiescomputer readable instructions, data structures, program modules, orother data in a modulated data signal, such as a carrier wave or othertransport mechanism, and includes any information delivery media. Theterm “modulated data signal” means a signal that has one or more of itscharacteristics set or changed in such a manner as to encode informationin the signal. By way of example, and not limitation, communicationmedia includes wired media, such as a wired network or direct-wiredconnection, and wireless media, such as acoustic, RF, infrared, andother wireless media. Combinations of any of the above should also beincluded within the scope of computer readable media.

The computer storage media, including database cluster 24, discussedabove and illustrated in FIG. 1, provide storage of computer readableinstructions, data structures, program modules, and other data forserver 22.

Server 22 may operate in a computer network 26 using logical connectionsto one or more remote computers 28. Remote computers 28 can be locatedat a variety of locations in a medical or research environment, forexample, but not limited to, clinical laboratories, hospitals, otherinpatient settings, a clinician's office, ambulatory settings, medicalbilling and financial offices, hospital administration, veterinaryenvironment and home healthcare environment. Clinicians include, but arenot limited to, the treating physician, specialists such as surgeons,radiologists and cardiologists, emergency medical technicians,physician's assistants, nurse practitioners, nurses, nurse's aides,pharmacists, dieticians, microbiologists, laboratory experts, geneticcounselors, researchers, veterinarians, students, and the like. Theremote computers may also be physically located in non-traditionalmedical care environments so that the entire healthcare community iscapable of integration on the network. Remote computers 28 may be apersonal computer, server, router, a network PC, a peer device, othercommon network node healthcare device or the like, and may include someor all of the elements described above relative to server 22. Thedevices can be personal digital assistants, or other like devices.Computer network 26 may be a local area network (LAN) and/or a wide areanetwork (WAN), but may also include other networks including Internetnetworks via wired or wireless capability. Such networking environmentsare commonplace in offices, enterprise-wide computer networks, intranetsand the Internet. When utilized in a WAN networking environment, server22 may include a modem or other means for establishing communicationsover the WAN, such as the Internet. In a networked environment, programmodules or portions thereof may be stored in server 22, or databasecluster 24, or on any of the remote computers 28. By way of example, andnot limitation, various application programs may reside on the memoryassociated with any one or all of remote computers 28. It will beappreciated that the network connections shown are exemplary and othermeans of establishing a communications link between the computers may beused.

A user may enter commands and information into server 22 or convey thecommands and information to the server 22 via remote computers 28through input devices, such as keyboards, pointing devices, commonlyreferred to as a mouse, trackball, or touch pad. Other input devices mayinclude a microphone, satellite dish, scanner, or the like. Commands andinformation may also be sent directly from a remote healthcare device tothe server 22. Server 22 and/or remote computers 28 may have any sort ofdisplay device, for instance, a monitor. In addition to a monitor,server 22 and/or computers 28 may also include other peripheral outputdevices, such as speakers and printers.

Although many other internal components of server 22 and computers 28are not shown, those of ordinary skill in the art will appreciate thatsuch components and their interconnection are well known. Accordingly,additional details concerning the internal construction of server 22 andcomputer 28 need not be disclosed in connection with the presentinvention.

Although the method and system are described as being implemented in aWINDOWS operating system, operating in conjunction with anInternet-based system, one skilled in the art would recognize that themethod and system can be implemented in any system supporting building asystem of test components for a healthcare orderable procedure. Ascontemplated by the language above, the methods and systems of thepresent invention may also be implemented on a stand-alone desktop,personal computer, or any other computing device used in a medicalenvironment or any of a number of other locations.

With reference to FIG. 2, a method 200 for building a system of testcomponents for an orderable procedure is shown. An orderable procedureincludes tests, screenings, medications or other clinically significantitems or processes that can be ordered by a clinician or otherhealthcare provider. The method can be applied to a variety of domains,both clinical and non-clinical. This method simplifies the steps takento design and build a molecular diagnostic laboratory system. At step202, an orderable procedure is received. The orderable procedure may beselected from a list of orderable procedures by a user, such as adatabase administrator. The user identifies the orderable procedure forwhich they are building a system representation.

At step 204, the orderable procedure is associated to a discreteontology concept. This is a concept that is a uniquely identifiedmolecular entity that is part of an ontology, such as the ontology forgenomic concepts described in commonly assigned U.S. application Ser.No. 11/028,262 entitled “Computerized System and Method for Creating andMaintaining an Ontology for Genomics Concepts”. For example, a discreteontology concept may be a human gene. Other discrete concepts mayinclude the discrete concepts identified above in the discussion of anontology for genomic concepts, a chemistry panel or other clinical test.At step 206, an election to build the system representation of testcomponents associated with the discrete ontology concept and orderableprocedure.

At step 208, the relationship path through an ontology, such as anontology for genomic concepts, is traversed to identify test componentsfor the ontology concept. In other words, the system uses the definedset of relationships between concepts in the ontology to traverse theontology for the discrete gene concept associated with the orderableprocedure to identify test components. Test components may includeassays, tests to be performed for a particular screening or orderableprocedure or likely results for an orderable procedure. For example, ifthe ontology is traversed for relationships for a discrete gene concept,the test components would be clinically significant gene mutations (suchas nucleotide variants). The test components are displayed at step 209.The selection of likely results or test components for the orderableprocedure is received at step 210. For example, a database administratorselects the test components that will be appropriate for their localinstitution. At step 212, based on the selections, a systemrepresentation for the orderable procedure is built based on theselections.

By way of example, and not by limitation, with reference to FIG. 3, ascreen 300 listing orderable procedures 302 is shown. The orderableprocedures include diagnostic screening for particular molecularentities, such as CFTR screening and RET screening. In FIG. 3, theorderable procedure 304 for RET screening is selected by a user. Withreference to FIG. 4, a screen 400 displaying details for the RETscreening 402 is shown. With reference to FIG. 5, a display 500 showingassociation of an orderable 502 for RET screening with a discreteontology concept 504 is shown. In this example, the association is doneby searching for the RET orderable procedure 504 and selecting anavigational concept 506 for the orderable procedure at the terminologyaxis level. In this example the human gene navigational concept 508 hasbeen selected by a user.

With reference to FIG. 6, a screen 600 displays that the RET screeningorderable procedure 604 has been associated with the discrete human geneconcept (gDNA)RET 608. The screen also displays that the RET screeningorderable procedure 604 has been associated with the human genenavigational concept 606. Based on the association of the RET screeningorderable procedure with the discrete concept (gDNA)RET 608, theontology for discrete gene concept (gDNA)RET is traversed. Using thedefining biological relationships of the ontology between discreteconcepts, the likely results or test components for (gDNA)RET can easilybe determined. In this example, the test components for (gDNA)RET areclinically significant gene mutations (such as nucleotide variants) for(gDNA)RET.

FIG. 7 is a screen 700 displaying the test components 708 in atask/assay batch build 702 for the discrete human gene concept (gDNA)RET706 associated with the RET screening orderable 704. The likely resultsor test components for the discrete human gene concept (gDNA)RET 706include tests for nucleotide variants such as RET.c.1825T>G andRET.c.1826G>A.

With reference to FIG. 8, a screen 800 displaying the selection by auser of test components is shown. The user has selected the testcomponents 806, 808, 810, 812 and 814 for discrete human gene concept(gDNA)RET 804 for the RET screening orderable procedure 802. The testscomponents selected include nucleotide variants: RET.c.1825T>G (806);RET.c.1826G>T (808); RET.c.1832G>C (810); RET.c.1852T>A (812); andRET.c.1853G>T (814).

Referring next to FIG. 9, is a display 900 for building a systemrepresentation of test components for an orderable procedure. The likelyresults or test components selected 906 are added to a task/assay list908 for the discrete human gene concept (gDNA)RET 904 associated withthe RET screening orderable procedure 902. Thus, in this example, theassays/test components 910 to be preformed for the RET screeningorderable procedure are RET.c.1825T>G, RET.c.1826G>T, RET.c.1832G>C,RET.c.1852T>A and RET.c.1853G>T. In other words, these are the likelysignificant genetic mutations that will be tested for when an RETscreening orderable procedure is ordered for a patient.

The present invention has been described in relation to particularembodiments, which are intended in all respects to be illustrativerather than restrictive. Alternative embodiments will become apparent tothose skilled in the art that do not depart from its scope. Manyalternative embodiments exist, but are not included because of thenature of this invention. A skilled programmer may develop alternativemeans for implementing the aforementioned improvements without departingfrom the scope of the present invention.

It will be understood that certain features and sub-combinations ofutility may be employed without reference to features andsub-combinations, and are contemplated within the scope of the claims.Not all steps listed in the various figures need to be carried out inthe specific order described.

1. A computer storage medium having embodied thereon computer-readableinstructions that, when executed by a computing device, enable thecomputing device to perform a method of identifying a test componentthat is usable to perform an orderable healthcare procedure, the methodcomprising: receiving as an input the orderable healthcare procedure,wherein the orderable healthcare procedure is associated with aparticular molecular entity; displaying on a device a navigationalconcept that represents a parent tier in an ontology hierarchy;responsive to input of the navigational concept, identifying a uniquelyidentified molecular entity that relates to the particular molecularentity and that is a child concept of the navigational concept;traversing biological relationships of the uniquely identified molecularentity to identify a potential test component of a task, which isexecuted to carry-out the orderable healthcare procedure; displaying thepotential test component to enable selection thereof; and upon receivinginput of the potential test component, displaying the potential testcomponent a test component of the task.
 2. The computer storage mediumof claim 1, wherein the orderable healthcare procedure includes adiagnostic screening that is usable to detect an existence of theparticular molecular entity in a sample.
 3. The computer storage mediumof claim 1, wherein the navigational concept is a sub-category within ahuman-genome tier of the ontology hierarchy.
 4. The computer storagemedium of claim 1, wherein the uniquely identified molecular entity is aspecific human gene.
 5. The computer storage medium of claim 1, whereinthe biological relationships link the specific human gene with anucleotide variant of the specific human gene.
 6. The computer storagemedium of claim 5, wherein the nucleotide variant is used to identifythe potential test component.
 7. The computer storage medium of claim 5,wherein the horizontal defining biological relationships span one ormore parent-child relationships.
 8. The computer storage medium of claim7, wherein the horizontal defining biological relationship is a knownbiological relationship between two molecular entities.
 9. Acomputerized system for building a system of test components, which areusable to perform an orderable healthcare procedure, the systemcomprising one or more programmed computers for performing a method, thesystem comprising: a receiving component that receives an input of theorderable healthcare procedure, wherein the orderable healthcareprocedure is associated with a particular molecular entity; anassociating component that, upon input of a navigational concept,associates the orderable healthcare procedure with a discrete ontologyconcept, (1) wherein the navigational concept includes a category ofmolecular entities that is a parent concept of said discrete ontologyconcept, and (2) wherein the discrete ontology concept includes auniquely identified molecular entity, a traversing component thattraverses an ontology of the discrete ontology concept to identify testcomponents related to the discrete ontology concept, wherein theontology comprises horizontal defining biological relationshipsassociating the discrete ontology concept with the test components; anda displaying component for displaying identified test components relatedto the discrete ontology concept.
 10. The system of claim 9, furthercomprising a second receiving component that receives an input of theidentified test components.
 11. The system of claim 10, furthercomprising a building component that, based on the input of theidentified test components, builds a system of test components that areusable to carry-out the orderable procedure.
 12. The system of claim 9,wherein the test components are discrete concepts within the ontology.13. The system of claim 12, wherein the test components are clinicallysignificant gene mutations.
 14. The system of claim 13, wherein the testcomponents are related to the discrete ontology concept by horizontaldefining biological relationships and wherein the horizontal definingbiological relationships span one or more parent-child hierarchies. 15.The system of claim 14, wherein the horizontal defining biologicalrelationship is a known biological relationship between two molecularentities.
 16. The system of claim 9, wherein the ontology is an ontologyof genomic concepts.
 17. A method, which is implemented using acomputing device, of identifying a test component that is usable toperform an orderable healthcare procedure, the method comprising:receiving as an input the orderable healthcare procedure, wherein theorderable healthcare procedure is associated with a particular molecularentity; displaying on a display device a navigational concept thatrepresents a parent tier in an ontology hierarchy; responsive to inputof the navigational concept, identifying by a processor a uniquelyidentified molecular entity that relates to the particular molecularentity and that is a child concept of the navigational concept;traversing biological relationships of the uniquely identified molecularentity to identify by the processor a potential test component of atask, which is executed to carry-out the orderable healthcare procedure;displaying the potential test component to enable selection thereof; andupon receiving input of the potential test component, displaying thepotential test component a test component of the task.
 18. The method ofclaim 17, wherein the orderable healthcare procedure includes adiagnostic screening that is usable to detect an existence of theparticular molecular entity in a sample.
 19. The method of claim 17,wherein the navigational concept is a sub-category within a human-genometier of the ontology hierarchy.
 20. The method of claim 17, wherein theuniquely identified molecular entity is a specific human gene.